Sull’acido folinico (chiamato anche leucovorin) Trump e Robert Kennedy junior hanno fatto le seguenti dichiarazioni President Trump is promising a new treatment for autism spectrum disorder: a prescription form of vitamin B9 called leucovorin. Robert Kennedy junior “It's an exciting therapy that may benefit large numbers of children who have suffered from autism” https://www.npr.org/sections/shots-health-news/2025/09/25/nx-s1-5552751/auti... L’American Academy of Pediatrics (AAP) ha precisato quanto segue We do not know how to identify who has CFD (cerbrale folic deficit) without a lumbar puncture or genetic testing. We do not know whether autistic children without CFD benefit from leucovorin. We do not have a best practice for dosing, nor does the FDA give guidance on this. We do not know how long patients should take it or what the risks of long-term high-dose leucovorin are. We do not have a validated protocol to measure responsiveness and track changes over time. More research is needed. Larger, well-designed, multisite trials using objective outcome measures are necessary to determine whether leucovorin is safe and effective in autism and in which subgroups it may be most beneficial for. More research is also needed to understand appropriate monitoring laboratory tests and dosing guidelines. https://www.aap.org/en/patient-care/autism/use-of-leucovorin-in-autistic-ped.... Daniela MC