Quoting [email protected]:
Nel 2004 era comparso uno studio con le conclusioni opposte con alcuni dei medesimi autori, accessibile gratuitamente sulla pagina: http://aje.oxfordjournals.org/cgi/reprint/161/10/916
SPal.
I due studi non sono in contrapposizione. il secondo non prende in considerazione il lutto della madre fra i fattori di rischio prenatali. Cito testualmente: Perinatal risk factors. The perinatal factors investigated were categorized as 1) delivery and newborn characteristics: fetal presentation, mode of delivery, Apgar score at 5 minutes, birth weight, gestational age at birth, and weight for gestational age; 2) pregnancy characteristics: multiple gestation, preeclampsia, and number of antenatal visits; and 3) parental characteristics: number of previous pregnancies, maternal smoking reported at the first antenatal visit, maternalcitizenship, and maternal and paternal ages. Birth weight for gestational age was categorized into three groups according to the gender-specific birth-weight distribution at a given gestational age in a sample of children (N = 97,596) born in Denmark between 1980 and 1994: small for gestational age (<10th centile), appropriate for gestational age (10th90th centile), and large for gestational age (>90th centile). Information about Apgar score, gestational age at birth, and birth weight for gestational age was available from 1978 only; information about preeclampsia and maternal smoking was collected for only the years 19781990 and 19911994, respectively. (Larsson et al., American Journal of Epidemiology, 161 (10): 916, 2005) Cordialmente Daniela Barcaroli ---------------------------------------------------------------- This message was sent using IMP, the Internet Messaging Program.
L'impressione di contradditorietà in alcuni studi sullo stress può dipendere dall'imprecisione terminologica. E' interessante che un altro lavoro proveniente dal medesimo centro suggerisca che nei pretermine e sottopeso lo stress del lutto aumenti la suscettibilità alla paralisi cerebrale infantile (v. sotto), mentre ciò non avverrebbe nell'autismo (articolo precedente). Sia in epidemiologia, sia in genetica, le manifestazioni cortisol-related potrebbero risultare diverse se si misura il lutto come stressor (life event) oppure come percezione di disagio (being stressed). Li J, Vestergaard M, Obel C, Precht DH, Christensen J, Lu M, Olsen J. *Prenatal Stress and Cerebral Palsy: A Nationwide Cohort Study in Denmark.* Psychosom Med. 2009 May 29. [Epub ahead of print] *Objectives*: Exposure to prenatal stress may affect neurodevelopment of the fetus, but whether this exposure increases the risk of cerebral palsy (CP) later in life is unknown. We aimed to examine the association between maternal bereavement during the prenatal time period and CP in childhood. *Methods*: We conducted a nationwide cohort study by linking information from nationwide registers. All 1,501,894 singletons born in Denmark from 1979 to 2004 were followed up from birth to the end of 2006. We identified 39,601 children whose mothers lost a close relative (child, spouse, parent, sibling) during pregnancy or up to 1 year before pregnancy and they were classified as the exposed group. The outcome of interest was the diagnosis of CP as registered in the National Hospital Register. We used Cox Regression to estimate the hazard ratios (HRs). *Results*: Exposure to maternal bereavement after the loss of a child during the prenatal period was associated with an increased risk of CP among children born preterm without intrauterine growth retardation (HR 2.26, 95% CI, 1.09-3.79) and among children born at term with intrauterine growth retardation (HR 2.01, 95% CI, 1.04-3.89). Prenatal stress after maternal bereavement by loss of other relatives was not associated with an increased risk of CP. *Conclusions*: Our data suggest that extremely severe stress in prenatal life could increase the susceptibility for CP among children born preterm or with impaired fetal growth. Saluti cordiali - SPal.
participants (2)
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barcarol＠uniroma2.it -
Dr Stefano Palazzi