[autismo-biologia] Fw: [2282] Autismo: 20% in piu' di connessioni
cerebrali
Stefano Palazzi
s.palazzi a ausl.fe.it
Lun 30 Ago 2010 22:59:44 CEST
Riguardo al ruolo della sinaptogenesi, come č interessante che un
deficit di potatura sinaptica nei primi mesi di vita porti
all'autismo, cosė lo č pure che un eccesso di potatura in adolescenza
possa portare a schizofrenia:
J Psychiatr Res. 1994 May-Jun;28(3):239-65.
Is schizophrenia due to excessive synaptic pruning in the prefrontal
cortex? The
Feinberg hypothesis revisited.
Keshavan MS, Anderson S, Pettegrew JW.
Department of Psychiatry, Western Psychiatric Institute and Clinic,
Pittsburgh,
PA 15213.
Several lines of evidence support the notion that a substantial
reorganization of
cortical connections, involving a programmed synaptic pruning, takes
place during
adolescence in humans. A review of neurobiological abnormalities in
schizophrenia
indicates that the neurobiological parameters that undergo peripubertal
regressive changes may be abnormal in this disorder. An excessive
pruning of the
prefrontal corticocortical, and corticosubcortical synapses, perhaps
involving
the excitatory glutamatergic inputs to pyramidal neurons, may underlie
schizophrenia. A reciprocal failure of pruning in certain subcortical
structures,
such as lenticular nuclei, may also occur. Several developmental
trajectories,
related to early brain insults as well as genetic factors affecting
postnatal
neurodevelopment, could lead to the illness. These models would have
heuristic
value and may be consistent with several known facts of the
schizophrenic
illness, such as its onset in adolescence and the gender differences
in its onset
and natural course. The relationship between these models and other
etiological
models of schizophrenia are summarized and approaches to test relevant
hypotheses
are discussed.
PMID: 7932285 [PubMed - indexed for MEDLINE]
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